DUSP1 (dual specificity phosphatase 1)
نویسندگان
چکیده
منابع مشابه
Dual specificity protein phosphatase 1 (DUSP1) in normal pregnancy and preeclampsia
Objectives: Preeclampsia is best described as a pregnancy-specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation. It is severe and clinically important manifestations of placental insufficiency. Our purpose was to study DUSP1 expression in normal human pregnancy and preeclampsia. Study design: We used ELISA, RT-PCR and Immuno-histochemistry to characteriz...
متن کاملTranscriptional Regulation of Human Dual Specificity Protein Phosphatase 1 (DUSP1) Gene by Glucocorticoids
BACKGROUND Glucocorticoids are potent anti-inflammatory agents commonly used to treat inflammatory diseases. They convey signals through the intracellular glucocorticoid receptor (GR), which upon binding to ligands, associates with genomic glucocorticoid response elements (GREs) to regulate transcription of associated genes. One mechanism by which glucocorticoids inhibit inflammation is through...
متن کاملDual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
Activation of the mitogen-activated protein kinase (MAPK) cascade after Toll-like receptor stimulation enables innate immune cells to rapidly activate cytokine gene expression. A balanced response to signals of infectious danger requires that cellular activation is transient. Here, we identify the MAPK phosphatase dual specificity phosphatase 1 (DUSP1) as an essential endogenous regulator of th...
متن کاملThe yeast open reading frame encoding a dual specificity phosphatase.
References 1 Gething, M. J. and Sambrook, J. (1992) Nature 355, 33-45 2 Lewis, M. J. and Pelham, H. R. B. (1992) Cell 68, 353-364 3 Kaiser, C. A. and Schekman, R. (1990) Cell 61, 723-733 4 Bennett, M. K., Calakos, M. and Scheller, R. H. (1992) Science 257, 255-259 5 Rothman, J. E. and Orci, L. (1992) Nature 355, 409-415 6 Quinn, P., Griffiths, G. and Warren G. (1984) J. Cell BioL 98, 2142-2147 ...
متن کاملDual-specificity phosphatase 23 mediates GCM1 dephosphorylation and activation
Glial cells missing homolog 1 (GCM1) is a transcription factor essential for placental development. GCM1 promotes syncytiotrophoblast formation and placental vasculogenesis by activating fusogenic and proangiogenic gene expression in placenta. GCM1 activity is regulated by multiple post-translational modifications. The cAMP/PKA-signaling pathway promotes CBP-mediated GCM1 acetylation and stabil...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2012
ISSN: 1768-3262
DOI: 10.4267/2042/48225